T cell receptor constant alpha chain gene +1592C/T polymorphism may not be associated with IgA nephropathy.
- Author:
Shi-liang LI
1
;
Xu LIN
;
Jie WANG
;
Fa-fen YANG
;
Yan-wu YOU
;
Peng-wei GUO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Asian Continental Ancestry Group; genetics; Child; Chromosomes, Human, Pair 14; Female; Gene Frequency; Genotype; Glomerulonephritis, IGA; genetics; Humans; Kidney; pathology; Male; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Receptors, Antigen, T-Cell, alpha-beta; genetics; Young Adult
- From: Journal of Southern Medical University 2010;30(10):2298-2300
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between T cell receptor constant alpha chain (TCRCα) gene +1592C/T polymorphism and IgA nephropathy.
METHODSTCRCα +1592C/T genotypes were identified by PCR-RFLP and direct sequencing in 244 Chinese Han patients with IgA nephropathy, who were classified according to their genotype into CC (188 cases), CT (54 cases) and TT (2 cases) groups. The clinical and pathological data of the patients were analyzed in relation to the TCRCα +1592C/T genotypes.
RESULTSNo significant differences in the clinical and biochemical indices were found in these patients with different TCRCα gene +1592C/T genotypes. TCRCα +1592C/T polymorphism was not found to contribute to severity or manifestations of renal pathology.
CONCLUSIONSTCRCα+1592C/T polymorphism may not be associated with the susceptibility to IgA nephropathy in the Chinese Han population.
