Relationship between D2-40-labeled lymphatic vessel invasion and lymph node metastasis of breast cancer.
- Author:
Gui-po DING
1
;
Chang-sheng YE
;
Min-feng LIU
;
Le-feng ZHEN
;
Jia-jian LIAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antibodies, Monoclonal; Breast Neoplasms; diagnosis; pathology; Female; Humans; Immunohistochemistry; methods; Lymph Nodes; pathology; Lymphatic Metastasis; diagnosis; pathology; Lymphatic Vessels; pathology; Middle Aged; Neoplasm Staging
- From: Journal of Southern Medical University 2010;30(10):2301-2303
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the feasibility of D2-40 labeling for detecting lymphatic vessels in breast cancer tissues and the clinicopathological implications of lymphatic vessel invasion (LVI).
METHODSImmunohistochemistry was used to detect the expression of D2-40 and lymphatic invasion in 72 cases of breast cancer and 15 benign breast tumor tissues, and their correlations to the clinicopathological factors were analyzed.
RESULTSThe positivity rate of LVI was 69.4% in breast cancer tissue. In patients with lymph node metastasis, the positivity rate of LVI was significantly higher than that in patients without lymph node involvement (85.7% vs 54.1%, P<0.01), and LVI was found to be positively correlated to axillary lymph node metastasis (r=0.382).
CONCLUSIOND2-40 can specially and reliably mark the lymphatic vessels in breast cancer tissues. LVI is positively correlated to axillary lymph node metastasis and occurs earlier than the latter, therefore should be included in routine clinicopathological testing.
