Effect of chronoexercise on circadian expression of clock genes.
- Author:
Kun-lin JIAN
1
;
Ying XU
;
Xiang-qian WANG
;
Dong-sheng AI
;
Li LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Circadian Rhythm; physiology; Cricetinae; Gene Expression; Period Circadian Proteins; genetics; metabolism; Physical Conditioning, Animal; RNA, Messenger; genetics; Reverse Transcriptase Polymerase Chain Reaction
- From: Journal of Southern Medical University 2010;30(10):2384-2395
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the molecular biological mechanism of chronoexercise regulating circadian.
METHODSExpressions of mPer1 and mPer2 in the diencephalon of golden hamster were determined 2 hours after acute exhaustive exercise (circadian time 6) by quantitative RT-PCR.
RESULTSChronoexercise at CT6 significantly decreased expressions of mPer1 and mPer2 in the diencephalon of golden hamster.
CONCLUSIONInhibitory effect of chronoexercise on Per1 and Per2 mRNA levels in the diencephalon of golden hamster at CT6 may be achieved transcription-translation-based autoregulatory negative feedback loop.
