Correlation between PTPN22 gene polymorphism and systemic lupus erythematosus in Chinese Han patients.
- Author:
Xue-biao PENG
1
;
Li-na OU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Asian Continental Ancestry Group; genetics; Case-Control Studies; Child; Exons; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Lupus Erythematosus, Systemic; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide; Protein Tyrosine Phosphatase, Non-Receptor Type 22; genetics; Young Adult
- From: Journal of Southern Medical University 2010;30(10):2390-2391
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between 1858C/T single nucleotide polymorphism on exon 14 of the protein tyrosine phosphatase nonreceptor-22 (PTPN22) gene and systemic lupus erythematosus in Chinese Han patients.
METHODSForty Chinese Han patients with SLE and 20 normal control subjects were enrolled in the study, and PTPN22 gene 1858 C/T polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
RESULTSNo significant difference was found in the CC, CT, and TT genotype frequencies or in the C and T allele frequencies between the SLE patients and the normal controls.
CONCLUSION1858C/T on PTPN22 gene might not be associated with the susceptibility of SLE in Chinese Han population.
