Effect of Sanhuangyinchi decoction on liver damage and caspase-3 in rats with acute hepatic failure.
- Author:
Yun-gao YANG
1
;
Ya-wei LIU
;
He-yu HUA
;
Li-jie LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; Caspase 3; metabolism; Drugs, Chinese Herbal; pharmacology; therapeutic use; Female; Liver; drug effects; metabolism; pathology; Liver Failure, Acute; drug therapy; metabolism; pathology; Male; Phytotherapy; Rats; Rats, Sprague-Dawley
- From: Journal of Southern Medical University 2010;30(11):2443-2445
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate effect of Sanhuangyinchi decoction (SHYCD) on liver damage and the pro-apoptotic factor caspase-3 in rats with acute hepatic failure.
METHODSSD rats were randomly divided into blank control group, model group, Angongniuhuang group (AGNH) and SHYCD group. Acute hepatic failure was induced in the rats by intraperitoneal injections of D-GaLN and LPS, and the death rate, ALT, TBIL, PT and caspase-3 activity was observed or tested.
RESULTSAt 36 h after the injections, the death rate of the rats was 74.29% (26/35) in the model group, 31.43% (11/35) in AGNH group and 28.57%(10/35) in SHYCD group. The death rate, ALT, TBIL, PT and caspase-3 activity in AGNH and SHYCD groups were significantly lower than those in the model group (P<0.01). SHYCD showed stronger effect than AGNH in depressing TBIL and the activity of caspase-3 (P<0.05).
CONCLUSIONSHYCD can improve the liver function and inhibit the activity of caspase-3 in rats, which can be the possible mechanism for its therapeutic effect against acute hepatic failure.
