Analysis of the factors related to glomerular filtration rate in type 2 diabetes without albuminuria.
- Author:
Xiao-hua LU
1
;
Lie FENG
;
Ya-bin JIANG
;
You-fen ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Albuminuria; complications; physiopathology; Diabetes Mellitus, Type 2; complications; epidemiology; physiopathology; Diabetic Nephropathies; physiopathology; Female; Glomerular Filtration Rate; Humans; Kidney; physiopathology; Male; Middle Aged; Prevalence; Risk Factors
- From: Journal of Southern Medical University 2010;30(11):2502-2504
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the risk factors affecting the glomerular filtration rate (GFR) in type 2 diabetic patients without albuminuria.
METHODSA total of 131 type 2 diabetic patients with normal urinary albumin excretion rate (UAER) were divided into normal GFR group and decreased GFR group. The factors relevant to GFR were analyzed by multiple factors regression.
RESULTSAge, course of diabetes, systolic blood pressure, prevalence of hypertension, the level of serum creatinine (SCr), blood urea nitrogen (BUN) and uric acid (UA) were significantly higher in decreased GFR group than in normal GFR group. Multivariate regression showed that SCr, age, systolic blood pressure, and UA were negatively correlated to GFR.
CONCLUSIONReduced GFR occurs in some type 2 diabetic patients without albuminuria. SCr, age, systolic blood pressure and UA are the major factors related to decreased GFR. The degree of early renal damage in diabetic patients can be better evaluated by combining GFR and UAER.
