Effect of percutaneous intratumoral injection of lipiodol emulsion of chemotherapie agents on implanted VX2 tumor in rabbits.
- Author:
Jin-wen SONG
1
;
Yan-hao LI
;
Yong CHEN
;
Yan YANG
;
Xiao-hong LIU
;
Ji-jun NING
;
Jun YANG
;
Xin-xia SHI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Emulsions; Injections, Intralesional; Iodized Oil; administration & dosage; therapeutic use; Neoplasms, Experimental; metabolism; pathology; therapy; Proliferating Cell Nuclear Antigen; metabolism; Rabbits; Vascular Endothelial Growth Factor A; metabolism
- From: Journal of Southern Medical University 2010;30(11):2526-2529
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the therapeutic effect of percutaneous intratumoral injection with lipiodol emulsion of chemotherapie agents (CALE) on implanted VX2 tumor in rabbits.
METHODSTwelve New Zealand rabbits with implanted VX2 tumor (24 models) were divided into lipiodol group, chemotherapeutic agent group and CALE group with intratumoral injections of the corresponding agents. The pathological changes of all the lesions were observed and the expression of proliferating cell nuclear antigen (PCNA) and vascular endothelial growth factor (VEGF) were evaluated 7 days after the operation.
RESULTSCompared with the lipiodol group and chemotherapie agent group, intratumoral injection of CALE resulted in the highest tumor necrosis rate and greatest tumor necrosis (P<0.01). The labeling indices of PCNA and VEGF expressions in CALE group were markedly lower than those in the other two groups (P<0.01).
CONCLUSIONPercutaneous intratumoral injection of CALE is an effective ablation approach for treatment of malignant solid tumors.
