Transformation of patient-derived tumor xenografts into lymphomas: characteristics, influence factors and precautions.
- Author:
Jianling ZOU
;
Jing GAO
;
Lin SHEN
1
Author Information
1. Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Key laboratory of Carcinogenesis and Translational Research(Ministry of Education), Beijing 100142, China. lin100@medmail.com.cn.
- Publication Type:Journal Article
- MeSH:
Animals;
B-Lymphocytes;
Disease Models, Animal;
Epstein-Barr Virus Infections;
Herpesvirus 4, Human;
Heterografts;
Humans;
Leukocyte Common Antigens;
Lymphoma;
Lymphoma, B-Cell;
Mice;
Mice, SCID;
Neoplasms;
Transplantation, Heterologous
- From:
Chinese Journal of Gastrointestinal Surgery
2016;19(7):833-837
- CountryChina
- Language:Chinese
-
Abstract:
The patient-derived tumor xenografts (PDX) model is an animal model established by directly engrafting fresh tumor tissue of patients into immunodeficiency mice after surgery or biopsy, which plays an important role in the study of tumor biology. However, the transformation of PDX into lymphoma limits the application of this model. The characters of this transformation include that epithelial tumors origin, predorminance of B-cell lymphomas, lost of architectural feature of primary tumor, absence of epithelial tumor markers, and CD45 and CD20 expression. That were characteristics of human B lymphocytes, and possible infection of Epstein-Barr virus(EBV). The biology of primary tumor, EBV infection, inflammation infiltration in primary tumors and the host immune status are the main related factors in this transformation. Therefore, selective xenograft by the detection of EBV infection and inflammation infiltration in primary tumors may be effective methods to prevent lymphomagenesis.
