Acute Effect of Methylprednisolone in Experimental Spinal Cord Injury.
- Author:
Dae Whan KIM
1
;
Kyu Man SHIN
Author Information
1. Department of Neurosurgery, Ewah Womans University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Spinal cord injury;
Methylprednisolone;
ATP;
Na+, K+-ATPase
- MeSH:
Adenosine Triphosphate;
Animals;
Cats;
Lipid Peroxidation;
Methylprednisolone*;
Neurons;
Spinal Cord Injuries*;
Spinal Cord*
- From:Journal of Korean Neurosurgical Society
1983;12(4):521-528
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It is the purpose of this study to determine the benificial effect of treatment with methylprednisolone on the enhancement of Na+, K+-ATPase activity and the increased ATP level during the 4 hours after a 400gm-cm injury to the spinal cord of cat. These results demonstrate that high dose (30mg/kg) of methylprednisolone can benificially enhance the activity of neuronal Na+, K+-ATPase during the first 4 hour after spinal cord injury. But the enhancement of this enzyme activity is not significantly increased with mega dose (60mg/kg) of methylprednisolone. Tissue level of ATP in the high dose-treated cat at 1 hour after trauma was significantly elevated, but those in high dose-treated cat at 4 hour and the 1 and 4 hours with mega dose-treated groups were not significantly increased. The protective effects of methylprednisolone in experimental spinal cord trauma are the enhancement of Na+, K+-ATPase, inhibition of the free-radical reaction and the lipid peroxidation, the increment of neuronal activity and ATP utilization. High dose(30mg/kg) of methylprednisolone is required in order to produce the acute effect in the early phase experimental spinal cord injury.
