Investigation on mechanism and drug kinetic release of sodium diclofenac microgranules
- Author:
Chau Minh Hoang
- Publication Type:Journal Article
- Keywords:
sodium diclofenac
- MeSH:
Diclofenac;
Pharmacokinetics
- From:Pharmaceutical Journal
2001;298(2):16-19
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The aim of this research is to investigate the mechanism and kinetics of drug release from the core and coated pellets containing sodium diclofenac. Avicel was found to be a good excipient to prepare matrix-type pellets. The drug release could be sustained up to 12 hours. the rate of drug release was fit to Higuchi's model. The microphotograph revealed that the drug release was controlled by the diffusion from the isoluble matrix. The drug release was sustained up to 24 hours. The rate of drug release was fit to Higuchi's model, too. The mechanism of drug release was determined to be the diffusion from insoluble matrix and through the insoluble membrane.
