High intensity focused ultrasound combined with endocrine therapy in treating prostate cancer.
- Author:
Li-xin HUA
1
;
Hong-fei WU
;
Yuan-geng SUI
;
Wei ZHANG
;
Li-xin QIAN
;
Ning-hong SONG
;
Jie-xiu ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; therapeutic use; Combined Modality Therapy; Flutamide; therapeutic use; Follow-Up Studies; Gonadotropin-Releasing Hormone; antagonists & inhibitors; therapeutic use; Humans; Male; Middle Aged; Orchiectomy; Prostatic Neoplasms; therapy; Treatment Outcome; Ultrasound, High-Intensity Focused, Transrectal
- From: National Journal of Andrology 2005;11(3):195-197
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the clinical efficacy of high intensity focused ultrasound (HIFU) combined with endocrine therapy in the treatment of patients with prostate cancer.
METHODSTwenty patients with prostate cancer were treated with extracorporeal HIFU device( model FEP-BY01 ) and androgen ablation, of whom 15 received orchiectomy and 5 LHRH-a. Fourteen patients of the total number were given flutamide in addition to castration.
RESULTSThe mean follow-up was 13.5 months (ranging 6 to approximately 30). Before and after the treatment, the prostate volume, prostate specific antigen (PSA), international prostate symptom score (IPSS) and maximal flow rate (Qmax) of the patients were (36.4 +/- 16.2) ml and (20.6 +/- 11.8) ml (P < 0.05), (32.2 +/- 10.4) ng/ml and (2.4 +/- 0.8) ng/ml (P < 0.01), 20. 5 +/- 6.5 and 13.6 +/- 7.5 (P < 0.05), (10.6 +/- 6.3) ml/s and (14.2 +/- 4.6) ml/s (P < 0.05), respectively. Mild hematuria and pain were noted in 5 and 8 patients respectively, and 1 patient underwent internal urethrotomy with a cold knife because of urethral stricture. er, with minimal complications.
CONCLUSIONHIFU combined with endocrine therapy is effective in the treatment of prostate canc-
