(CAG) n polymorphism of androgen receptor gene in idiopathic azoospermic and oligospermic Chinese men.
- Author:
Zuo-Xiang LI
1
;
Wen-Hao TANG
;
Zhao-Hui WANG
;
Lin WANG
;
Yuan-Yuan WANG
;
Lu-Lin MA
;
Xu MA
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Electrophoresis, Polyacrylamide Gel; Exons; Humans; Infertility, Male; genetics; Male; Oligospermia; genetics; Polymerase Chain Reaction; Polymorphism, Genetic; Receptors, Androgen; genetics; Trinucleotide Repeats; genetics
- From: National Journal of Andrology 2005;11(5):335-342
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo research (CAG)n polymorphism of androgen receptor gene in idiopathic azoospermic and oligospermic Chinese men, and to explore its correlation with the development of dyszoospermia.
METHODSFifty-two men with oligospermia and 31 with azoospermia were enrolled, the number of CAG sequence repeats determined by PCR and denaturing polyacrylamide gel electrophoresis (PAGE), and (CAG)n polymorphism analyzed.
RESULTSThe CAG repeats in the men with oligospermia and those with azoospermia were 22.19 and 22.13 respectively.
CONCLUSIONThe polymorphism of the repeat length of the (CAG) n satellite in androgen receptor gene may affect spermatogenesis and have a less important role in male infertility.
