Effects of growth hormone supplementation on erectile function and expression of nNOS in aging rats.
- Author:
Xian-Sheng ZHANG
1
;
Yi-Xin WANG
;
Yin-Fa HAN
;
Zheng LI
;
Zu-Qiong XIANG
;
Jing LENG
;
Xu-Yuan HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apomorphine; pharmacology; Growth Hormone; pharmacology; Immunohistochemistry; Male; Nitric Oxide Synthase Type I; biosynthesis; Papaverine; pharmacology; Penile Erection; drug effects; Penis; enzymology; innervation; Random Allocation; Rats; Rats, Sprague-Dawley
- From: National Journal of Andrology 2005;11(5):339-342
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effects of growth hormone( GH) supplementation on erectile function and expression of nNOS in the intracavernosal nerves in aging rats.
METHODSTwenty male Sprague-Dawley rats aged 18 months were randomly divided into Groups A and B, and ten 2-month-old male Sprague-Dawley rats included in Group C. 1 U/(kg x d) GH was given to Group A, and the same volume of saline to Groups B and C. After 8 weeks of treatment, evaluation was made of the erections induced by apomorphine (APO), maximal intracavernous pressure (ICP) induced by intracavernous papaverine injection and expression of nNOS in the intracavernosal nerves by streptavidin-peroxidase immunohistochemical techniques.
RESULTSAfter 8 weeks of treatment, the erection frequency, maximal ICP and expression of nNOS in the intracavernosal nerves of the rats in Groups A and C were significantly higher than those in Group B (P < 0.05 or P < 0.01).
CONCLUSIONGrowth hormone supplementation can improve the erectile function of aging rats, which may be attributed to the increase in the expression of nNOS in the intracavernosal nerves.
