Significance of MMP2 and MMP9 expression in prostate cancer.
- Author:
Xiao-Yi ZHANG
1
;
Bao-Fa HONG
;
Guang-Fu CHEN
;
Ya-Li LU
;
Mei ZHONG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Humans; Immunohistochemistry; Male; Matrix Metalloproteinase 2; biosynthesis; Matrix Metalloproteinase 9; biosynthesis; Middle Aged; Neoplasm Metastasis; Prostatic Neoplasms; metabolism; pathology
- From: National Journal of Andrology 2005;11(5):359-364
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the significance of the expression of matrix metalloproteinases (MMPs) in prostate cancer (PCa) and its clinical association.
METHODSFifty one cases of PCa and 10 cases of BPH were studied by immunohistochemical method using monoclonal antibodies to MMP2 and MMP9.
RESULTSThere was significant correlation between MMP2 or MMP9 and pathological grade, Gleason score and PCa metastasis.
CONCLUSIONThe expression of MMP2 and MMP9 may play an important role in the development and metastasis of PCa.
