Association between polymorphism of CYP17 gene and serum hormone concentrations in aged men.
- Author:
Jun-Qi WANG
1
;
Xiang GU
;
Jia-Cun CHEN
;
Xiao-Qing SUN
;
Hong-Tao MU
;
Zeng-He WEI
;
Ming LI
;
Dian-Qi XIN
;
Yan-Qun NA
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Estradiol; blood; Genotype; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Promoter Regions, Genetic; genetics; Steroid 17-alpha-Hydroxylase; genetics; Testosterone; blood
- From: National Journal of Andrology 2005;11(6):442-444
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between polymorphism of CYP17 gene and serum hormone concentrations in aged men.
METHODSEighty-three healthy men at the average age of 66.7 were divided into a < 66.7 group (n = 36) and a > 66.7 group (n = 47), and the polymorphism of CYP17 gene in the 5' promoter region was investigated by PCR using DNA from the men's peripheral blood lymphocytes. A new recognition site was created for the restriction enzyme MspA1 I by transition (T --> C) in the risk allele (A2). Three genotypes A1/A1, A1/A2, A2/A2 were established, serum sex-hormone levels measured, and mean hormone concentration evaluated in each genotype and age group.
RESULTSNo evidence was found that the testosterone (T) level, estrogen (E2) level and T/E2 ratio were associated with the genotype of CYP17 gene. There was no significant difference in T and E2 levels between the two groups, but there was a significant increase in the T/E2 ratio (P < 0.05).
CONCLUSIONA2 allele does not increase sex hormone levels in aged men, but the T/E, ratio was higher in the > 66.7 group than in the < 66.7 group. This may be closely associated with the mechanism of benign prostate hyperplasia and prostate cancer in aged men.
