Expression of TGF-beta1 mRNA in prostate carcinoma tissues and its significance.
- Author:
Ze-liang LI
1
;
Ye YANG
;
Zhen-hua LI
;
Chui-ze KONG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Humans; Male; Middle Aged; Neoplasm Staging; Prostatic Neoplasms; metabolism; pathology; RNA, Messenger; genetics; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta; biosynthesis; genetics
- From: National Journal of Andrology 2005;11(7):511-513
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of TGF-beta1 mRNA in prostate carcinoma tissues and its significance.
METHODSRT-PCR method was used to examine the expression of TGF-beta1 mRNA in normal and carcinomatous prostate tissues.
RESULTSThe relative content of TGF-beta1 mRNA of normal prostate tissues was (0.74 +/- 0.11), while those of carcinomatous prostate tissues at T1-T2 and T3-T4 stages were (0.69 +/- 0.10) and (0.44 +/- 0.08) respectively, with significant difference between T1-T2 and T3-T4 (P < 0.05). And the relative contents of TGF-beta1 mRNA of carcinomatous prostate tissues with Gleason score < or = 5, 6-8 and > or = 9 were (0.70 +/- 0.12), (0.54 +/- 0.11) and (0.42 +/- 0.09) respectively.
CONCLUSIONThe expression of TGF-beta1 mRNA was negatively correlated with the clinical stage and Gleason score of prostate carcinoma.
