Advances in the study of p53 in response to DNA damage.
- Author:
Ya-Jie WANG
1
;
Hua SUN
;
Geng-Tao LIU
;
Xiao-Guang CHEN
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Apoptosis;
Cell Cycle;
Cell Line, Tumor;
Cell Proliferation;
DNA Damage;
DNA Repair;
Genes, p53;
Humans;
Proto-Oncogene Proteins c-mdm2;
metabolism;
Signal Transduction;
Tumor Suppressor Protein p53;
genetics;
physiology
- From:
Acta Pharmaceutica Sinica
2011;46(12):1413-1419
- CountryChina
- Language:Chinese
-
Abstract:
p53 (encoded by TP53) is undoubtedly one of the most extensively studied genes and proteins. It is a highly potent transcription factor which, under normal circumstances, is maintained at low level. Both genotoxic and non-genotoxic stresses can induce p53 stabilized leading to changes in the expression of p53-responsive genes. The biological outcome inducing this pathway can be either growth arrest and apoptosis or senescence to maintain the integrity of the genome or to delete the damaged cells. The biochemical activity of p53 itself and the cellular environment govern the choice between these outcomes in a cell type- and stress-specific manner. So, p53 is a pivotal tumour suppressor and a mainstay of our body's natural anticancer defence. This review could provide some useful information for further study on the mechanisms of tumorigenesis and its progression, and also could contribute to the discovery of antitumor agents.
