Advances in the study of Mycobacterium tuberculosis protein phosphatase and its inhibitors.
- Author:
Tie-Shan TENG
1
;
Hong-Hai WANG
;
Jian-Ping XIE
Author Information
1. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing 400715, China.
- Publication Type:Journal Article
- MeSH:
Acid Phosphatase;
antagonists & inhibitors;
metabolism;
Animals;
Antitubercular Agents;
pharmacology;
Bacterial Proteins;
antagonists & inhibitors;
metabolism;
Humans;
Mycobacterium tuberculosis;
drug effects;
enzymology;
Protein Tyrosine Phosphatases;
antagonists & inhibitors;
metabolism
- From:
Acta Pharmaceutica Sinica
2011;46(12):1420-1428
- CountryChina
- Language:Chinese
-
Abstract:
Reversible protein phosphorylation regulates multiple biochemical events. Mycobacterium tuberculosis phosphatases play important roles in regulating the pathogen physiology and interference of host signaling. They are also involved in the evasion of host immune response and blockage of the phagosome-lysosome fusion. Selective inhibition of phosphatase represents an ideal new avenue of anti-tuberculosis drug design. In this paper, we update the progresses about the regulation network of Mycobacterium tuberculosis phosphatases including MptpA, MptpB, MstP, SapM and their inhibitors. These serve as the basis for further antituberculosis drug target.
