Characterization of vinflunine tartrate liposomes in vitro and in vivo.
- Author:
Wei-Wei ZOU
1
;
Dong-Hai WANG
;
Chun-Yan SUN
;
Jing-Bin HAN
;
Qing YIN
;
Qing-Min YANG
;
Jing-Yi WANG
Author Information
1. Shandong Provincial Key Laboratory of Microparticle Drug Delivery Technology, Jinan 250100, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents, Phytogenic;
administration & dosage;
chemistry;
pharmacology;
toxicity;
Cell Line, Tumor;
Drug Carriers;
Drug Compounding;
Drug Delivery Systems;
Drug Stability;
Female;
Humans;
Liposomes;
Lung Neoplasms;
pathology;
Mice;
Mice, Inbred BALB C;
Mice, Nude;
Neoplasm Transplantation;
Particle Size;
Random Allocation;
Tartrates;
administration & dosage;
chemistry;
pharmacology;
toxicity;
Tumor Burden;
drug effects;
Vinblastine;
administration & dosage;
analogs & derivatives;
chemistry;
pharmacology;
toxicity
- From:
Acta Pharmaceutica Sinica
2011;46(12):1515-1519
- CountryChina
- Language:Chinese
-
Abstract:
Vinflunine tartrate-loaded liposomes (VT-L) with two drug-to-lipid ratios were prepared by pH gradient method. Vesicle size and zeta potential were determined by the Zetasizer Nano ZS. Entrapment efficiency was evaluated by cation exchange resin centrifugalization method. The toxicity and tumor inhibition to nude mouse administrated by VT-L with different drug-to-lipid ratios were investigated and compared with the vinflunine tartrate injection (VT-I). The results showed that the mean particle size, zeta potential and entrapment efficiency of the VT-L with drug-to-lipid ratios of 1 : 5 and 1 : 10 were 124.6 nm and 128.3 nm, -25.3 mV and -22.8 mV, 94.46% and 97.31%, respectively. The VT-L with two different drug-to-lipid ratios has significantly higher anti-tumor effect to nude mouse transplanted human non-small cell lung carcinoma A549 and lower toxicity than VT-I. While there were no significant differences in anti-tumor effect and toxicity between VT-L with two different drug-to-lipid ratios.
