Role of stress in depression insomnia and sleep characteristics of commonly used animal stress models.
- Author:
Yi-Ying LI
1
;
Zhen-Zhen HU
;
Zhi-Li HUANG
;
Su-Rong YANG
Author Information
1. Department of Pharmacology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Chronic Disease;
Depression;
physiopathology;
Depressive Disorder;
physiopathology;
Disease Models, Animal;
Humans;
Hypothalamo-Hypophyseal System;
physiopathology;
Pituitary-Adrenal System;
physiopathology;
Sleep;
physiology;
Sleep Initiation and Maintenance Disorders;
physiopathology;
Sleep, REM;
Stress Disorders, Post-Traumatic;
physiopathology;
Stress, Psychological;
physiopathology
- From:
Acta Pharmaceutica Sinica
2012;47(1):1-6
- CountryChina
- Language:Chinese
-
Abstract:
Depression and insomnia are intimately related. Depressed patients usually manifest sleep discontinuity and early awakening, reduced or no slow wave sleep (SWS) and shortened latency of rapid eye movement (REM) sleep. These sleep abnormalities are very similar to those caused by over activated hypothalamic-pituitary-adrenal (HPA) axis with stress. Therefore, the animal models developed by post-traumatic stress disorder or chronic unpredictable mild stress could be used to evaluate drugs which have effects of both anti-depression and improvement of sleep quality, and to provide a more reliable platform for further studis on the mechanisms of depression and accompanied insomnia. This review mainly focuses on the typical features of sleep disturbance of depression, possible pathophysiological mechanisms, establishment of animal stress models and analysis of their abnormal sleep characteristics.
