Anti-lipotoxic action of sesamin on renovascular hypertensive rats fed with a high-fat, high-sucrose diet.
- Author:
Xiang-Qi WU
1
;
Jie-Ren YANG
Author Information
1. Department of Pharmacology, Wannan Medical College, Wuhu 241001, China.
- Publication Type:Journal Article
- MeSH:
Adipocytes;
drug effects;
Animals;
Anticholesteremic Agents;
administration & dosage;
pharmacology;
Antihypertensive Agents;
administration & dosage;
pharmacology;
Blood Glucose;
metabolism;
Blood Pressure;
drug effects;
Body Weight;
drug effects;
Cholesterol;
blood;
Diet, High-Fat;
Dioxoles;
administration & dosage;
pharmacology;
Dose-Response Relationship, Drug;
Fatty Acids, Nonesterified;
blood;
Glucose Tolerance Test;
Hypertension, Renovascular;
blood;
pathology;
Insulin;
blood;
Insulin Resistance;
Interleukin-6;
blood;
Islets of Langerhans;
pathology;
Lignans;
administration & dosage;
pharmacology;
Liver;
pathology;
Male;
Pancreas;
pathology;
Rats;
Rats, Sprague-Dawley;
Sucrose;
Triglycerides;
blood;
Tumor Necrosis Factor-alpha;
blood
- From:
Acta Pharmaceutica Sinica
2012;47(1):58-65
- CountryChina
- Language:Chinese
-
Abstract:
This study is to observe anti-lipotoxic effect of sesamin on renovascular hypertensive rats fed with a high-fat, high-sucrose diet. Thirty-four complex model rats were induced by two-kidney, one-clip method and on high-fat and refined-carbohydrate diet for thirteen weeks. From the fifth week, intragastric administration of sesamin (120, 60 and 30 mg x kg(-1) x d(-1)) lasted for eight weeks. Blood pressure (BP), blood fat (BF), blood glucose (BG), free fatty acids (FFA), insulin (Ins), tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 were determined. Pathological changes of pancreas, perirenal fat and liver were semiquantitatively analyzed. In sesamin (120 and 60 mg x kg(-1) x d(-1)) group, it was found that there were decrease of levels of BP, BF, BG, TNF-alpha, IL-6 and FFA, improvement of insulin resistance and glucose tolerance, alleviation of body weight, humid weight of fat, liver and pancreas and their organ index, and reduction of islet cell hyperplasia and amount of lipid droplet vacuoles in lipocyte and hepatocyte. It is implied that sesamin had anti-lipotoxic effect and its mechanism may be closely associated with the amelioration of insulin resistance via reducing lipidoses in hepatocyte and inflammatory adipokines such as TNF-alpha and IL-6.
