Regulatory mechanism underlying pathogen biofilm formation and potential drug targets.
- Author:
Ting-Yu SHI
1
;
Wan-Yan DENG
;
Jian-Ping XIE
Author Information
1. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School ofLife Sciences, Southwest University, Chongqing 400715, China.
- Publication Type:Journal Article
- MeSH:
Acyl-Butyrolactones;
metabolism;
Bacteria;
genetics;
metabolism;
Bacterial Proteins;
genetics;
metabolism;
Biofilms;
growth & development;
Drug Delivery Systems;
Gene Expression Regulation, Bacterial;
Homoserine;
analogs & derivatives;
metabolism;
Lactones;
metabolism;
Quorum Sensing;
Signal Transduction
- From:
Acta Pharmaceutica Sinica
2012;47(2):135-143
- CountryChina
- Language:Chinese
-
Abstract:
Bacterial communities usually develop biofilms abound in nature niche. The development of biofilm is a highly dynamic and complex process coordinated by multiple mechanisms, of which two-component system and quorum sensing are two well-defined systems. Biofilm is involved in the virulence of many pathogens. Therefore, targeting the key factors involved in the biofilm formation represents a novel and promising avenue for developing better antibiotics.
