Mass spectrometry technology and its application in analysis of biological samples.
- Author:
Long-Shan ZHAO
1
;
Qing LI
;
Chao-Wei GUO
;
Xiao-Hui CHEN
;
Kai-Shun BI
Author Information
1. School ofPharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Drug-Related Side Effects and Adverse Reactions;
Humans;
Mass Spectrometry;
methods;
Metabolomics;
Pharmaceutical Preparations;
chemistry;
Pharmacokinetics;
Pharmacology;
Therapeutic Equivalency
- From:
Acta Pharmaceutica Sinica
2012;47(2):158-162
- CountryChina
- Language:Chinese
-
Abstract:
With the excellent merits of wide analytical range, high sensitivity, small sample size, fast analysis speed, good repeatability, simple operation, low mobile phase consumption, as well as its capability of simultaneous isolation and identification, etc, mass spectrometry techniques have become widely used in the area of environmental science, energy chemical industry, biological medicine, and so on. This article reviews the application of mass spectrometry technology in biological sample analysis in the latest three years with the focus on the new applications in pharmacokinetics and bioequivalence, toxicokinetics, pharmacokinetic-pharmacodynamic, population pharmacokinetics, identification and fragmentation pathways of drugs and their metabolites and metabonomics to provide references for further study of biological sample analysis.
