Application research of hot-melt extrusion in preparation of solid dispersion.
- Author:
Mei-Wan CHEN
1
;
Wen-Rong CHEN
;
Tong-Kai CHEN
;
Rui-E CHEN
;
Yi-Tao WANG
Author Information
1. The State key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
- Publication Type:Journal Article
- MeSH:
Biological Availability;
Chemistry, Pharmaceutical;
Dosage Forms;
Drug Carriers;
Drug Compounding;
Hot Temperature;
Pharmaceutical Preparations;
chemistry;
Pressure;
Solubility;
Technology, Pharmaceutical;
methods
- From:
Acta Pharmaceutica Sinica
2012;47(2):163-167
- CountryChina
- Language:Chinese
-
Abstract:
Hot-melt extrusion (HME) is mainly used to enhance the dissolution rate and bioavailability of poorly water soluble drugs. It has many advantages, such as simple process, continuous operation, high efficiency, on-line monitoring and so on. HME provides an innovative approach, which has been concerned by pharmaceutical workers, for preparation of solid dispersion abroad. This article reviews recent advances on preparation of solid dispersion by HME in preparation processing, carrier materials and quality evaluation in order to further promote and apply HME in preparation of solid dispersion.
