Coumarins of Anemone raddeana Regel and their biological activity.
- Author:
Feng-Zhi REN
1
;
Shu-Hong CHEN
;
Zhi-Hui ZHENG
;
Xue-Xia ZHANG
;
Li-Hong LI
;
Ai-Hua DONG
Author Information
1. New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Microbial Medicine Engineering and Research Center, Shijiazhuang 050015, China.
- Publication Type:Journal Article
- MeSH:
Anemone;
chemistry;
Antineoplastic Agents, Phytogenic;
chemistry;
isolation & purification;
pharmacology;
Cell Line, Tumor;
Cell Proliferation;
drug effects;
Coumarins;
chemistry;
isolation & purification;
pharmacology;
Humans;
Inhibitory Concentration 50;
Leukocyte Elastase;
metabolism;
Molecular Structure;
Plants, Medicinal;
chemistry;
Receptors, Retinoic Acid;
genetics;
metabolism;
Retinoic Acid Receptor alpha;
Rhizome;
chemistry;
Transcriptional Activation
- From:
Acta Pharmaceutica Sinica
2012;47(2):206-209
- CountryChina
- Language:Chinese
-
Abstract:
To study the coumarins of Anemone raddeana Regel, the compounds were separated by silica gel column chromatography and HPLC. Their structures were identified by their physicochemical property and spectral analysis. Two new compounds were isolated and identified as 4, 7-dimethoxyl-5-methyl-6-hydroxy coumarin (1) and 4, 7-dimethoxyl-5-formyl-6-hydroxycoumarin (2). The bioassays indicated that compounds 1 and 2 could significantly inhibit the proliferation of cancer cell, and showed the agonist effect on the transactivity of retinoic acid receptor-alpha (RARalpha). In addition, the two compounds had inhibitory effect against human leukocyte elastase (HLE).
