The preparation of paeonol transdermal delivery systems based on the microemulsion-based gels and its pharmacokinetics characters.
- Author:
Ji-Yong LIU
1
;
Ying HAN
;
Jin-Hong HU
;
Zheng-Tao WANG
;
Kai-Xian CHEN
Author Information
1. Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
- Publication Type:Journal Article
- MeSH:
Acetophenones;
administration & dosage;
blood;
metabolism;
pharmacokinetics;
Administration, Cutaneous;
Animals;
Biological Availability;
Chromatography, Liquid;
Drug Delivery Systems;
Emulsions;
Gels;
Male;
Mass Spectrometry;
Microdialysis;
Rats;
Rats, Sprague-Dawley;
Skin;
metabolism;
Skin Absorption
- From:
Acta Pharmaceutica Sinica
2012;47(2):244-249
- CountryChina
- Language:Chinese
-
Abstract:
Investigation of the pharmacokinetics of paeonol microemulsion, microemulsion-based gels and marketed paeonol ointments by the skin-blood synchronous microdialysis coupled with LC/MS is reported in this study. The microdialysis systems were established by linear probes and concentric circles probes. In vivo recovery of paeonol in skin is (69.7 +/- 4.8) % and in blood is (51.6 +/- 7.2)%. The paeonol microemulsion, microemulsion-based gels and marketed paeonol ointments were administered to rats. PBS (pH 7.4) served as perfused solution. The perfusion rate was 5 microL x mL(-1) and the microdialysis samples were collected every 20 min intervals. The paeonol concentration in perfused solution was determined by LC/MS. The results showed that paeonol microemulsion and microemulsion-based gels significantly raised the drug concentrations in skin more than that of paeonol ointments. The paeonol microemulsion-based gels has similar bioavailability as the paeonol ointments in blood, but its blood drug concentrations were steadier. The paeonol microemulsion-based gels may be developed into a new preparation for dermis eczema. The skin-blood synchronous microdialysis technique proved to be a new method for the pharmacokinetics study of transdermal delivery systems.
