Progress in the study of some important natural bioactive cyclopeptides.
- Author:
Wen-Yan XU
1
;
Si-Meng ZHAO
;
Guang-Zhi ZENG
;
Wen-Jun HE
;
Hui-Min XU
;
Ning-Hu TAN
Author Information
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Anti-Bacterial Agents;
chemical synthesis;
chemistry;
pharmacology;
Antineoplastic Agents;
chemical synthesis;
chemistry;
therapeutic use;
Cyclosporine;
chemistry;
pharmacology;
Daptomycin;
chemical synthesis;
chemistry;
pharmacology;
Depsipeptides;
chemical synthesis;
chemistry;
therapeutic use;
Gramicidin;
chemical synthesis;
chemistry;
pharmacology;
Humans;
Immunosuppression;
Immunosuppressive Agents;
chemical synthesis;
chemistry;
pharmacology;
Molecular Structure;
Neoplasms;
drug therapy;
Peptides, Cyclic;
chemical synthesis;
chemistry;
pharmacology;
therapeutic use;
Quantitative Structure-Activity Relationship;
Vancomycin;
chemical synthesis;
chemistry;
pharmacology
- From:
Acta Pharmaceutica Sinica
2012;47(3):271-279
- CountryChina
- Language:Chinese
-
Abstract:
Natural cyclopeptides are hot spots in chemical and pharmaceutical fields because of the wide spreading bio-resources, complex molecular structures and various bioactivities. Bio-producers of cyclopeptides distribute over almost every kingdom from bacteria to plants and animals. Many cyclopeptides contain non-coded amino acids and non-pepditic bonds. Most exciting characteristic of cyclopeptides is a range of interesting bioactivities such as antibiotics gramicidin-S (2), vancomycin (3) and daptomycin (4), immunosuppressive cyclosporin-A (1) and astin-C (8), and anti-tumor aplidine (5), RA-V (6) and RA-VII (7). Compounds 1-4 are being used in clinics; compounds 5-8 are in the stages of clinical trial or as a candidate for drug research. In this review, the progress in chemical and bioactive studies on these important natural bioactive cyclopeptides 1-8 are introduced, mainly including discovery, bioactivity, mechanism, QSAR and synthesis.
