Sirtuin1 and lung disease.
- Author:
Ji SHI
1
;
Ai-Min MENG
;
Qi HOU
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Asthma;
metabolism;
Benzamides;
pharmacology;
Humans;
Lung Diseases;
metabolism;
Lung Neoplasms;
metabolism;
Naphthols;
pharmacology;
Protein Processing, Post-Translational;
Pulmonary Disease, Chronic Obstructive;
metabolism;
Sirtuin 1;
antagonists & inhibitors;
metabolism;
physiology;
Stilbenes;
pharmacology
- From:
Acta Pharmaceutica Sinica
2012;47(4):417-420
- CountryChina
- Language:Chinese
-
Abstract:
Sirtuin1 (Sirt1) is a NAD-dependent class III histone deacetylase (HDAC), and regulates pulmonary immune/inflammatory system and the aging process mainly through post-translational modification. Sirt1 could become a potential target for treatment of lung diseases due to participating in the development of a variety of lung diseases. In this paper, physiological characteristics, biological activities, modification regulations and its relationship with chronic obstructive pulmonary emphysema, asthma and lung cancer are reviewed.
