Research progress of liver X receptor agonists.
- Author:
Yu LIANG
1
;
Chang-Bin GUO
;
Chong ZHANG
;
Zhen-Geng HOU
Author Information
1. Department of Chemistry, Capital Normal University, Beijing 100048, China.
- Publication Type:Journal Article
- MeSH:
ATP-Binding Cassette Transporters;
metabolism;
Amines;
chemical synthesis;
chemistry;
pharmacology;
Animals;
Atherosclerosis;
drug therapy;
metabolism;
Benzimidazoles;
chemical synthesis;
chemistry;
pharmacology;
Cholesterol;
analogs & derivatives;
pharmacology;
Glucose;
analogs & derivatives;
pharmacology;
Humans;
Lipid Metabolism;
Lipogenesis;
Liver X Receptors;
Orphan Nuclear Receptors;
agonists;
physiology;
Quinolines;
chemical synthesis;
chemistry;
pharmacology;
Sterol Regulatory Element Binding Protein 1;
metabolism
- From:
Acta Pharmaceutica Sinica
2012;47(4):427-433
- CountryChina
- Language:Chinese
-
Abstract:
Liver X receptor (LXR), a member of the superfamily of nuclear receptors, plays an important role in the activation of transcription factors involved in cholesterol metabolism, glucose homeostasis inflammation and lipogenesis. It is shown that LXR agnoists have the potentiality to be used as drugs for the prevention and treatment of atherosclerosis, which is its best investigated therapeutic indication. There are many compounds being studied in preclinical evaluation and biological assay. This paper will review briefly the LXR agonists in recent years.
