Progress in the study of acid-sensitive micelles for the targeting drug delivery system.
- Author:
Rong-Bin HUANG
1
;
Guo-Tao TANG
Author Information
1. Institute of Pharmacy & Pharmacology, University of South China, Hengyang 421001, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antibiotics, Antineoplastic;
administration & dosage;
pharmacology;
Antineoplastic Agents, Phytogenic;
administration & dosage;
pharmacology;
Cell Line, Tumor;
Doxorubicin;
administration & dosage;
pharmacology;
Drug Carriers;
chemistry;
Drug Delivery Systems;
Humans;
Hydrogen-Ion Concentration;
Lactates;
chemistry;
Micelles;
Paclitaxel;
administration & dosage;
pharmacology;
Polyethylene Glycols;
chemistry;
Polymers
- From:
Acta Pharmaceutica Sinica
2012;47(4):440-445
- CountryChina
- Language:Chinese
-
Abstract:
As a novel targeting drug delivery system, acid-sensitive micelles have many advantages, such as increasing solubility of lipophilic drugs, acid-sensitive release, high drug loading, etc. They can load drugs though non-covalent encapsulation and covalent conjugation methods. In tumor tissues, drugs are released quickly from the depolymerized micelles with lipophilic copolymer protonation or lypohydrophilic copolymer hydrolysis and covalent conjugated drugs are released when the acid-sensitive covalent linkage breaks. This review mainly advances acid-sensitive micelles for the tumor targeting drug delivery systems from drug-loaded methods and release mechanisms.
