Anticancer Effect of Curcumin on B Cell non- Hodgkin's Lymphoma
- Author:
Chunyan SUN
1
;
Xinyue LIU
;
Yan CHEN
;
Fang LIU
Author Information
1. Union Hospital, Tongji Medical college, Huazhong and Technology
- Keywords:
Raji cell;
curcumin;
apoptosis;
cell cycle;
selectivity
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2005;25(4):404-407
- CountryChina
- Language:Chinese
-
Abstract:
To explore the anticancer effect of curcumin on human B cell non-Hodgkin's lymphoma and compare its effects on human B cell non-Hodgkin's lymphoma cells and normal peripheral blood mononuclear cells (NPBMNCs). MTT assay was used to study the effect of curcumin on the growth of Raji cells and NPBMNCs. The effect of curcumin on the apoptosis of Raji cells and NPBMNC were studied by flow cytometry and TDT-mediated dUTP nick and labeling (TUNEL). The effect of curcumin on the cell cycle of Raji cells were examined by propidium iodide staining flow cytometry. The results showed that curcumin strongly inhibited ±1.82 μmol/L and curcumin induced Raji cell apoptosis in a time- and dose-dependent manner. Raji cells treated with curcumin showed curcumin did not demonstrate apparent proliferation inhibition and apoptosis induction in NPBMNCs. It was concluded that curcumin is able to inhibit the proliferation of Raji cells by regulating the cell cycle and inducing the cell apoptosis. Morever, curcumin has low toxicity on NPBMNCs but can selectively induce apoptosis in Raji cells.
