Changes in Behavior and Amino Acid Neurotransmitters in the Brain of Rats with Seizure Induced by IL-1β or IL-6
- Author:
Xiaoqin ZHU
1
;
Zhengli LI
;
Changgeng ZHU
;
Xiaojing WANG
;
Li LI
Author Information
1. Huazhong University of Science and Technology
- Keywords:
epilepsy;
IL-1β;
IL-6;
glutamine;
GABA;
immunoreaction;
rat
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2005;25(3):236-239
- CountryChina
- Language:Chinese
-
Abstract:
Summary: To explore the mechanism of epilepsy induced by IL-1β and IL-6, the changes of glutamic acid (Glu) and GABA immunoreaction in the cerebral cortex and hippocampus of rats with seizure induced by IL-1β or IL-6 were studied. Rats were randomly divided into 3 groups: control group (intracerebroventricular injection (icv) of NS), IL-1β group (icv injection of IL-1β) and IL-6 group (i.c.v. injection of IL-6). 120 min after the icv injection of reagents of IL-1β or IL-6, behavioral changes were observed and Glu and GABA in the cerebral cortex and hippocampus were examined by means of immunohistochemistry. Our results showed that no seizure developed in the control group, while moderate seizure was observed in IL-1β group and IL-6 group. Compared with the controls, the immunoreaction of Glu was significantly increased, while GABA was obviously decreased in IL-1β group and IL-6 group after 120 min. Our study suggested that the IL-1β and IL-6 might promote and induce epilepsy by increasing Glu and decreasing GABA in the cerebral cortex and hippocampus.
