Detection of serum anti-F antibody in hepatitis C virus infected patients.
- Author:
Xiao-zhao DENG
1
;
Churn-mei JIANG
;
Ke XU
;
Zhong-can WANG
;
Wei-liang DING
;
Rong-bin YU
;
Jie WANG
;
Chao WU
;
Yun ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; China; Enzyme-Linked Immunosorbent Assay; Female; Hepacivirus; immunology; Hepatitis Antibodies; blood; Hepatitis C; immunology; Hepatitis C Antigens; immunology; Humans; Male; Middle Aged; Prevalence; Viral Core Proteins; immunology; Young Adult
- From: Chinese Journal of Epidemiology 2007;28(11):1116-1118
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the prevalence of serum anti-F in patients with hepatitis C virus (HCV) infection and the distribution of anti-F.
METHODSThe recombinant protein (HCV-F/GST) was coated onto micro titer plates as antigen. Sera of 120 patients with hepatitis C virus infection, 15 patients with hepatitis B, 3 patients with hepatitis E and 10 normal sera were tested by indirect ELISA for detecting anti-F.
RESULTS82 samples out of the 120 (68%) HCV infected patients exhibited a positive anti-F reaction, showing significant difference from the controls with no HCV infection (P < 0.01). Data from logistic analysis showed that the positive rate of anti-F was higher in patients over 50 year olds (OR = 6.675, 95% CI: 2.407-19.071). Patients of midrange, severe phase and hepatic cirrhosis had higher rate than the others (OR = 2.749, 95% CI: 1.470-5.141).
CONCLUSIONPrevalence and distribution of anti-F in Yixing hepatitis C patients was reported and which might be related to the progression of HCV infection.
