Roles of hypertension and serum leptin in obstructive sleep apnea hypopnea syndrome.
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征与高血压及瘦素的关系
- Author:
Rong HUANG
1
;
Yi XIAO
;
Xu ZHONG
;
Ming LI
;
Xi-zhen HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; Humans; Hypertension; etiology; Leptin; blood; Male; Middle Aged; Sleep Apnea, Obstructive; blood; complications; physiopathology
- From: Acta Academiae Medicinae Sinicae 2010;32(2):157-161
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the roles of hypertension and serum leptin in obstructive sleep apnea hypopnea syndrome (OSAHS).
METHODSTotally 60 patients with OSAHS (OSAHS group) and 40 age- and body mass index (BMI)-matched non-OSAHS individuals (non-OSAHS group) were enrolled in this study. The neck circumference (NC), waist/hip rate (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), leptin, fasting blood glucose (FBG), triglyceral (TG), cholesterol (Chol), and true insulin (TI) were measured before and after sleep . The correlations between hypertension/serum leptin level and OSAHS were analyzed.
RESULTSThe blood pressure(in the morning), especially DBP was significantly higher in OSAHS group than in non-OSAHS control group (89.75+/-2.04) mmHg vs. (81.63+/-1.91) mmHg, P<0.01. DBP in OSAHS group was positively correlated with serum leptin and apnea hypopnea index (AHI) (r=0.282, P<0.05; r=0.318, P<0.01). Logistic regression analysis showed that BMI (P=0.029), heart rate in the morning (P =0.030), and leptin (P=0.049) were independently correlated with the development of hypertension.
CONCLUSIONSOSAHS may independently affect blood pressure, especially DBP, after waking up. BMIHR in the morning and serum leptin may be the independent correlates of hypertension.
