Combination of methotrexate injection through hysteroscopic tubal catheterization and mifepristone per os in the conservative treatment of tubal pregnancy.
- Author:
Hui ZHAO
1
;
Bao-Jun YANG
;
Li-Min FENG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Drug Therapy, Combination; Female; Humans; Hysteroscopy; Injections; Methotrexate; administration & dosage; therapeutic use; Mifepristone; therapeutic use; Pregnancy; Pregnancy, Tubal; drug therapy; Young Adult
- From: Acta Academiae Medicinae Sinicae 2010;32(3):315-319
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the value of the combination of methotrexate(MTX) injection through hysteroscopic tubal catheterization and mifepristone per os in the conservative treatment of tubal pregnancy.
METHODSForty patients who met the criteria of conservative treatment were enrolled in this study and received the combined therapy of MTX 50 mg/d injection through hysteroscopic tubal catheterization and oral mifepristone 100mg/d for 5 days.
RESULTSOf these 40 patients, 38 (95.0%) were cured. The human chorionic gonadotropin decreased to normal level within 3-48 days. The masses disappeared within 16-65 days. The menstruation returned normal within 28-42 days. No obvious side effect was observed. Of 30 patients who underwent hydrotubation through hysteroscopy three months later, 12 patients were unobstructed, 2 patients were completely obstructed, and 16 patients were partially obstructed. Five patients had full-term deliveries up to this report.
CONCLUSIONThe combination of MTX injection through hysteroscopic tubal catheterization and mifepristone per os is safe and effective for early tubal pregnancy.
