Application of timolol in preventing variceal hemorrhage in patients with portal hypertension.
- Author:
Zhong-hua SHANG
1
;
Hai-yun CHEN
;
Hong-lin DONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Female; Gastrointestinal Hemorrhage; etiology; prevention & control; Humans; Hypertension, Portal; complications; Ligation; Male; Middle Aged; Timolol; therapeutic use; Young Adult
- From: Acta Academiae Medicinae Sinicae 2010;32(5):553-556
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo determine the effectiveness of timolol in preventing first variceal hemorrhage in portal hypertensive patients with esophageal varices.
METHODSA total of 42 cirrhotic patients with esophageal varices were enrolled in this study and received timolol or band ligation therapy randomly,with 21 patients in each group. The diameters of portal vein (PV), superior mesenteric vein (SMV), and splenic vein (SPV) as well as the portal venous flow and the splenic venous flow were measured. The first esophageal variceal bleeding of the two groups was recorded.
RESULTSThe diameters of PV, SMV, and SPV as well as the flow of PV and SPV showed no significant difference before and after treatment in band ligation group (P>0.05). In timolol group,however,the diameter of portal vein significantly decreased after treatment [(14.11±2.96) mm vs. (12.15±1.61)mm, P<0.05], and the average blood flow of portal vein also significantly decreased after treatment [(1277.33±495.19) ml/min vs. (719.17±245.16)ml/min, P<0.05]. Both timolol and band ligation effectively prevented esophageal variceal bleeding, and the risk of first esophageal variceal bleeding in these two groups were not significantly different (15% vs. 10%, P<0.05).
CONCLUSIONSTimolol is safe and effective in preventing the first variceal bleeding in portal hypertensive patients with esophageal varices.
