Study on the relationship of balanced translocation t(1;12) with spermatogenesis.
- Author:
Zuo-Min ZHOU
1
;
Jia-Yin LIU
;
Min XU
;
Jia-Hao SHA
;
Min LIN
;
Ya-Dong ZHOU
;
Li-Rong WANG
;
Jian-Min LI
Author Information
- Publication Type:Case Reports
- MeSH: Adult; Biopsy; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 12; Diseases in Twins; genetics; Humans; Infertility, Male; genetics; Male; Spermatogenesis; genetics; Testis; pathology; Translocation, Genetic; genetics
- From: National Journal of Andrology 2002;8(4):247-249
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo investigate the relationship between chromosome balanced translocation t(1;12) (q24;q24) and spermatogenesis in infertile twin brothers.
METHODSFor twin brothers, karotype were determined. The levels of testosterone, FSH and LH were detected. YRRM1, DAZ and DYS240 were analyzed. In younger brother a biopsy was taken from testis.
RESULTSChromosome analysis for both twin brothers revealed a karotype of 46, XY, t(1;12) (q24;q24). Sperm count was less than 1.0 x 10(6)/ml. There was no deletion for YRRM1, DAZ and DYS240 gene on Y chromosome. Photomicrograph of seminiferous tubules showed the arrest of spermatogenesis.
CONCLUSIONSChromosome balanced translocation t(1;12) (q24;q24) may be the cause of the spermatogenesis arrest in infertile twin brothers. Gene in the point of translocation may be related to spermatogenesis.
