The establishment of testicular fibrosis model in Wistar rats.
- Author:
Tao WANG
1
;
Yu-Mei MA
;
He-Ming XIU
;
Qu-Sheng ZHAO
;
Hui-Chen SUN
;
Zheng XU
;
Chang-En BEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Autoimmune Diseases; pathology; Disease Models, Animal; Fibrosis; Male; Mycobacterium bovis; Orchitis; pathology; Rats; Rats, Wistar; Testis; pathology
- From: National Journal of Andrology 2002;8(4):266-269
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo establish the testicular fibrosis model in rats.
METHODSWistar rats were divided into control group(n = 12) and model group(n = 40) randomly. Testicular fibrosis model was built with the classical method of establishing experimental autoimmune orchitis (EAO) combined with injecting Bacille Calmette-Guerin (BCG) into left testis.
RESULTSThe incidence rate of EAO and the rate of testicular fibrosis were 100%, 11.1% and 100%, 81.5% at 80, 140 days after the first infection, respectively.
CONCLUSIONSThe model of rat testicular fibrosis was established successfully.
