Effects of chlorotriptolide and triptonide on chromosome aberration and micronuclei of bone marrow cell in male rats.
- Author:
Jian-Wei ZHANG
1
;
Qi-Lan LIU
;
Ning LIN
;
Ye XU
;
Shao-Zhen QIAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Marrow Cells; drug effects; metabolism; Chromosome Aberrations; chemically induced; Diterpenes; pharmacology; Epoxy Compounds; Infertility, Male; chemically induced; genetics; Male; Micronuclei, Chromosome-Defective; drug effects; Phenanthrenes; Rats; Rats, Sprague-Dawley; Tripterygium; chemistry; Triterpenes; pharmacology
- From: National Journal of Andrology 2002;8(6):408-410
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo observe the effects of chlorotriptolide (T4) and triptonide (T7) on the chromosome aberration and micronuclei rates of bone marrow cell in male SD rats.
METHODSAntifertility doses of T4[80 micrograms/(kg.d)] or T7[317 micrograms/(kg.d)] were given to male rats per OS for 10 weeks. Bone marrow slides were then prepared and compared with the controls.
RESULTSThe chromosome aberration and micronuclei rates were not significantly different from those of the controls (P > 0.05).
CONCLUSIONSThe results were in accordance with our previous reports about the effects of T4 and T7 on the chromosome aberration and micronuclei rates of rat spermatogenic cells. At the antifertility doses, T4 and T7 did not show a mutagenic effect.
