Progress on Y chromosome microdeletions and male infertility.
- Author:
Gui-Mei YAO
1
;
Gui-An CHEN
Author Information
1. Reproductive Medicine Center, Peking University Third Medical School, Beijing 100083, China.
- Publication Type:Journal Article
- MeSH:
Chromosome Deletion;
Chromosome Mapping;
Chromosomes, Human, Y;
genetics;
Genotype;
Humans;
Infertility, Male;
genetics;
pathology;
Male;
Phenotype;
Sex Chromosome Aberrations
- From:
National Journal of Andrology
2002;8(6):445-448
- CountryChina
- Language:Chinese
-
Abstract:
About 10%-15% of azoospermic and 5%-10% of severely oligozoospermic men with idiopathic infertility have Yq microdeletions which could be transmitted to their male offspring by means of ICSI. We review present studies about Yq microdeletions including incidence, region, correlations between genotype and phenotype, the mechanism of Yq deletions and try to further understand the cause of male infertility as well as provide a new way for diagnosis and therapy.
