Clinical Study of 40 Cases with Mycosis Fungoides.
- Author:
Hyung Su KIM
1
;
Jong Hee LEE
;
Kwang Hyun CHO
Author Information
1. Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. khcho@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Mycosis fungoides;
Korean
- MeSH:
Age of Onset;
Diagnosis;
Disease Progression;
Drug Therapy;
Female;
Humans;
Incidence;
Korea;
Lymphoma, T-Cell, Cutaneous;
Male;
Mycosis Fungoides*;
Patient Care;
Prognosis;
Retrospective Studies;
Skin
- From:Korean Journal of Dermatology
2004;42(6):682-688
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Mycosis fungoides (MF) is the most common form of cutaneous T cell Lymphoma (CTCL). In Korea, the incidence rate of MF is very low and few clinical reviews have been done. OBJECTIVE: To investigate the clinical characteristics and treatment status of MF in Koreans. METHODS: A retrospective clinical study was made on 40 cases of MF patients. RESULTS: The mean age of onset was 45.3 years and the male to female ratio was approximately 1: 1. However, in the more advanced diseases, male patients were more frequent. According to the clinical stage by skin lesion at diagnosis, 26 were patch stage, 9 were plaque stage, and 5 were tumor stage patients. Two of the nine plaque stage patients had shown disease progression to the tumor stage. Twelve of the forty patients had been performed staging work up. The mean number of treatment modalities per patient was 1.53 with less in the early stages and more in the late stages being used. In the early stage, topical steroid was most commonly used and next were PUVA, UVB, and radiation therapy. For the advanced lesions, radiation therapy was most commonly used. The effect of chemotherapy was not good because it was used in refractory disease or extracutaneous diseases. In 40 MF patients, only one patient had died due to MF progression and most of the patients have shown stationary disease courses. Two patients have maintained complete remission. CONCLUSION: MF in Koreans shows some characteristics such as an earlier onset, less advanced stage, and better prognosis. It is necessary to perform staging work up at diagnosis not only for better patient care but also for more exact clinical studies.
