Experimental study of corpus cavernosal nerve evoked potential in diabetic rats.
- Author:
Kai GUO
1
;
Xian-Hui WANG
;
Yi WANG
;
Zheng-Yi WANG
;
Fu-Wen ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Diabetes Mellitus, Experimental; complications; physiopathology; Erectile Dysfunction; etiology; Evoked Potentials; Male; Nitric Oxide; physiology; Penis; innervation; Rats; Rats, Sprague-Dawley; Streptozocin
- From: National Journal of Andrology 2003;9(3):181-183
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo observe the cavernosal nerve dysfunction of diabetic Sprague Dawley rats.
METHODSThirty-five Sprague-Dawley rats were divided randomly into diabetes model group(n = 25) and normal group(n = 10). Diabetes model was established by administration of streptozotocin (63 mg/kg) in single intraperitoneal dosing. Giving single wave stimulus, corpus cavernosal nerve was measured for its latent period of reaction and myopotential.
RESULTSCompared with other groups, diabetic rats had longer reflection latent period(P < 0.01) and higher corpus cavernosum smooth muscle myopotential (P < 0.01).
CONCLUSIONSThe results indicate that corpus cavernosal nerve dysfunction may play an important role in the erectile dysfunction of diabetic rats.
