Study of sexual hormone changes in prostate cancer patients before and after androgen deprivation therapy.

Author: Jun YING ¹ ; De-Hong YAO ; Xiao-Ming REN
Author Information

1. Department of Urology, Shanghai Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
Publication Type:Journal Article
MeSH: Aged; Aged, 80 and over; Androgen Antagonists; therapeutic use; Gonadal Steroid Hormones; blood; Humans; Male; Middle Aged; Prostatectomy; Prostatic Neoplasms; blood; therapy
From: National Journal of Andrology 2003;9(3):191-196
CountryChina
Language:Chinese
Abstract:
OBJECTIVESTo investigate and observe serum sexual hormone (testosterone, T; free testosterone, FT; dihydrotestosterone, DHT) changes in patients with prostate cancer (PCa) before and after androgen deprivation.
METHODSSerum T, FT, DHT were measured with radioimmunoassay in 16 cases with PCa respectively one week before and the fifth day after androgen deprivation. The changes of T, FT, DHT were analyzed.
RESULTSSerum T, FT, DHT declined 92.27%, 92.26%, 58.36% respectively. They were statistically significant before and after androgen deprivation (P < 0.001).
CONCLUSIONSAfter androgen deprivation, most T and FT were deprived while DHT declined 58.36% only. Androgen receptor competitor shall be applied continually to prohibit the action of remnant androgen.