Relationship between polymorphism sites of Tim-3 and allergic rhinitis in a population of Uigurs and Hans from Xinjiang Uigur Autonomous Region of China
10.3760/cma.j.issn.1673-0860.2011.09.003
- VernacularTitle:新疆维吾尔族和汉族人群Tim-3基因多态性与变应性鼻炎的相关性研究
- Author:
Yan WANG
1
;
Zhi-Lian LIU
;
Jie SUN
;
Imam ILHAM
;
Hai-Fang HU
;
Hua ZHANG
Author Information
1. 新疆医科大学第一附属医院
- Keywords:
Rhinitis,allergic,perennial;
Rhinitis,allergic,seasonal;
Polymorphism,single nucleotide;
Membrane proteins
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2011;46(9):712-717
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find the relationship between the polymorphism of the Tim-3 gene mononucleotide site rs10515746 ( -574G ＞T), rs4704853( -882C ＞T), rs13170556, rs6555849 and the allergic rhinitis (AR) susceptibility in a population of Uigurs and Hans from Xinjiang Uigur Autonomous Region of China. Methods The two mononucleotide polymorphism site of Uigur and Han AR patients and normal people were analyzed in Xinjiang in terms of SNaPshot SNP typing technique. The gene type and alleomorph frequency were than caculated. According to the Tim-3 gene layout, the gene type and the allelomorph frequency had been calculated. The Hardy-Weinberg balance law had been used for exam ination. Results There were no statistic differences between the genotype and alleles of each frequency [ site rs10515746( -574G ＞ T), rs4704853 ( - 882C ＞ T), rs13170556 and rs6555849 )]of Uighurs, in group AR and matched group ( all P＞0.05). There were no statistic differences between the genotype and alleles of each frequency of Han people in group AR and matched group ( all P ＞ 0.05 ). Except Han cases site rs4704853, the distribution of other genotype and alleles of each frequency accord with heredity balance through the Hardy-Weinberg balance law. Conclusions In Xinjiang Uigur autonomous region, locus of gene Tim-3, site rs10515746( - 574G ＞ T), rs4704853 ( - 882C ＞ T), rs13170556 and rs6555849, has the polymorphism of the Tim-3 gene mononucleotide. There is no correlation between AR susceptibility and Tim-3 gene mononucleotide site of Uigur people and Han people in Xinjiang.
