Efficacy of Prophylactic Antibiotics in Dermatological Punch biopsy.
- Author:
So Jin KIM
1
;
Phil Seung SEO
;
Dong O YOU
;
Seok Don PARK
Author Information
1. Department of Dermatology, Wonkwang University School of Medicine, Iksan, Korea. sdpark@wonkwang.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Punch biopsy;
Prophylactic antibiotics
- MeSH:
Anti-Bacterial Agents*;
Bacteroides fragilis;
Biopsy*;
Demography;
Edema;
Erythema;
Humans;
Prospective Studies;
Skin;
Skin Diseases;
Staphylococcus aureus;
Staphylococcus epidermidis;
Wound Infection
- From:Korean Journal of Dermatology
2004;42(6):724-727
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Punch biopsy has been used frequently as a diagnostic method in dermatologic field. However dermatologist administrated antibiotics is routine for the prevention of wound infection. OBJECTIVE: The purpose of this study was to evaluate the efficacy of prophylactic antibiotics in punch biopsy. METHODS: Four hundred and one patients undergoing punch biopsy were studied prospectively. Patients were randomly split in to two groups: group I received prophylactic antibiotics after punch biopsy (197 patients), group II didn't receive any antibiotic after punch biopsy (204 patients). Wound infection was defined as a condition of erythema, edema, and pain or purulent discharge. RESULTS: Patients demographics and skin disease were similar between two groups. Biopsy site were infected in 3 patients of group I and 5 patients of groups II. Staphylococcus aureus, Staphylococcus epidermidis and Bacteroides fragilis were isolated from the infected biopsy site. There was no significant difference of infection rate between two groups. CONCLUSION: This result suggests that the routine use of prophylactic antibiotics after skin punch biopsy is unnecessary.
