Clinical analysis of 6 cases of primary small cell carcinom of the larynx
10.3760/cma.j.issn.1673-0860.2011.09.013
- VernacularTitle:原发性喉小细胞癌六例临床分析
- Author:
Tao XU
1
;
Yuan-Hong GAO
;
Ping CHEN
;
Ge WEN
;
Le-Hui DU
;
Feng-Jun CAO
;
Hong-Xia JING
;
Meng-Zhong LIU
Author Information
1. 湖北医药学院附属人民医院
- Keywords:
Carcinoma,small cell;
Laryngeal neoplasms;
Combined modality therapy
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2011;46(9):758-760
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical characteristics, pathological features, diagnosis,therapy and prognosis of primary small cell carcinoma of the larynx (PSCCL). Methods Six cases of PSCCL collected from 1990 to 2009 was retrospectively analyzed. The diagnosis was confirmed by pathological examination. Among six patients, one case belonged to stage Ⅲ, and the others were in stage ⅣA. One case abandoned treatment; one case received chemotherapy; one case underwent supraglottic hemilaryngectomy and adjuvant chemoradiotherapy; one case underwent induction chemotherapy, radiotherapy and consolidation chemotherapy. Two cases received induction chemotherapy, concurrent chemoradiation and consolidation chemotherapy. The drug regimens included bleomycin, fluorouracil,cisplatin, etoposide and taxel for 3 -6 cycles. The radiotherapy technique included conventional radiotherapy, CT-Sim and three dimensional conformal radiation therapy with 60Co or 4 MV X-ray for 60 -66 Gy during 6 - 7 weeks. Results The time of follow-up was 3 - 24 months and the median was 13 months. Two patients applied with concurrent chemoradiation were alive without tumor. The patient abandoning therapy died of respiratory failure, and the others died of lung or liver metastasis after 8 -12 months. Conclusions PSCCL is a disseminated disease, so the pretreatment evaluation is nessesary.Concurrent chemoradiation is an ideal treatment model for this disease.
