Sporadic fundic gland polyps are not associated with proton pump inhibitors therapy but negatively correlate with Helicobacter pylori infection in China.

Hailong Cao; Rui QU; Zhihua Zhang; Xinyue Kong; Shan Wang; Kui Jiang; Bangmao Wang

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Sporadic fundic gland polyps are not associated with proton pump inhibitors therapy but negatively correlate with Helicobacter pylori infection in China.

Author: Hailong CAO ¹ ; Rui QU ² ; Zhihua ZHANG ³ ; Xinyue KONG ¹ ; Shan WANG ¹ ; Kui JIANG ¹ ; Bangmao WANG ⁴
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1. Department of Gastroenterology and Hepatology, Tianjin General Hospital, Tianjin Medical University, Tianjin 300052, China.
2. Department of Gastroenterology and Hepatology, Dongying People's Hospital, Dongying, Shandong 257091, China.
3. Department of Epidemiology, Anhui Medical University, Hefei, Anhui 230032, China.
4. Department of Gastroenterology and Hepatology, Tianjin General Hospital, Tianjin Medical University, Tianjin 300052, China. Email: gi.tmuh@yeah.net.
Publication Type:Journal Article
MeSH: Adenomatous Polyps; epidemiology; Adult; Aged; China; epidemiology; Endoscopy, Digestive System; Female; Gastric Fundus; drug effects; pathology; Helicobacter Infections; epidemiology; Humans; Male; Middle Aged; Proton Pump Inhibitors; adverse effects; Retrospective Studies; Stomach Neoplasms; epidemiology
From: Chinese Medical Journal 2014;127(7):1239-1243
CountryChina
Language:English
Abstract:
BACKGROUNDSporadic fundic gland polyps (FGPs) are common gastric polyps. Some studies reported that FGPs dramatically increased due to proton pump inhibitors (PPIs) use and a decreased prevalence of Helicobacter pylori (H. pylori) infection in Western countries. However, data are still controversial. This study aimed to identify the relationships between these two factors and FGPs in China.
METHODSConsecutive patients with FGPs detected were retrospectively analyzed. Data including patients' age, sex, symptoms, H. pylori infection, history of PPIs use, and the polyps were documented. Each patient was compared with two randomly selected age- and sex-matched controls with similar symptoms in the same period.
RESULTSDuring the period from March 2011 to March 2012, a total of 328 patients were diagnosed as FGPs in 23 047 patients who underwent routine esophagogastroduodenoscopy and 656 patients without FGPs as controls. The mean age was (55.12±12.61) years, and 75.91% were women. The prevalence of H. pylori in patients with FGPs was significantly lower than in those without FGPs (22.30% (64/287) vs. 42.26% (224/530), P < 0.001, OR 0.392, 95% CI 0.283-0.544). Overall, a total of 54 patients with FGPs (54/328, 16.46%) and 136 patients without FGPs (136/656, 20.73%) received PPIs therapy (P = 0.110). According to the different duration of PPIs use, no significant differences of PPIs use were found between the cases and controls among all subgroups. Moreover, the PPIs use was also similar, regardless of age, sex, H. pylori infection, and the number of polyps.
CONCLUSIONSporadic FGPs may not be induced by PPIs therapy but negatively correlate with H. pylori infection in China, which is not the same with the data in Western countries.