Preoperative platelet-lymphocyte ratio is an independent prognostic factor for resectable colorectal cancer.
- Author:
Hailiang LIU
1
;
Xiaohui DU
;
Peiming SUN
;
Chunhong XIAO
;
Yingxin XU
;
Rong LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Blood Platelets; cytology; Colorectal Neoplasms; diagnosis; mortality; Female; Humans; Lymphocyte Count; Lymphocytes; cytology; Male; Middle Aged; Platelet Count; Prognosis; Retrospective Studies; Survival Rate
- From: Journal of Southern Medical University 2013;33(1):70-73
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the impact of preoperative platelet-lymphocyte ratio (PLR) on the prognosis in patients with operable colorectal cancer.
METHODSThe clinical data of 140 patients with operable colorectal cancer were analyzed retrospectively. According to preoperative PLR, the patients were divided into low PLR group (PLR<250) and high PLR group (PLR≥250). The overall 5-year survival rates and the clinicopathological factors in the two groups were analyzed using univariate analysis and COX regression model.
RESULTSThe patients with a high PLR had a significantly lower overall 5-year survival rate than those with a low PLR (71.4% vs 51.5%, P=0.045). Univariate analyses identified tumor location, the depth of tumor invasion, lymph nodes metastasis, TMN stage, and PLR as significant risk factors for reduced overall 5-year survival. In COX regression model, a high PLR was identified as an independent risk factor for poorer prognosis in patients with resectable colorectal cancer (RR: 2.213; 95%CI: 1.007-4.863, P=0.0048).
CONCLUSIONPreoperative PLR can be a clinically significant factor for assessment of prognosis of resectable colorectal cancer.
