Reactivity of intrapulmonary arterial rings to thromboxane A2 and endothelin-1 is reduced in patients with chronic obstructive pulmonary disease.
- Author:
Yijing CHEN
1
;
Chunyu DENG
;
Sujuan KUANG
;
Jue MA
;
Guodong ZHAO
;
Guangyan ZHANG
;
Jianxiu CUI
Author Information
- Publication Type:Journal Article
- MeSH: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; pharmacology; Aged; Endothelin-1; metabolism; Female; Humans; In Vitro Techniques; Indomethacin; pharmacology; Male; Middle Aged; Pulmonary Artery; metabolism; Pulmonary Disease, Chronic Obstructive; metabolism; Thromboxane A2; metabolism
- From: Journal of Southern Medical University 2013;33(3):360-364
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the reactivity of intrapulmonary arterial rings to vasoactive substances as thromboxane A2 and endothelin-1 in patients with chronic obstructive pulmonary disease (COPD).
METHODSIntrapulmonary arterial rings isolated from patients with normal lung function and COPD were mounted in a Multi Myograph system to determine the reactivity of the intrapulmonary arterial rings to 60 mmol/L KCl, thromboxane A2 analogue U46619 and endothelin-1 before and after preconditioning with the COX synthase inhibitor indomethacin.
RESULTSThe reactivity of intrapulmonary arterial rings to U46619 and endothelin-1 was significantly decreased in patients with COPD. The reactivity to U46619 was dramatically decreased in patients with normal lung function after application of indomethacin.
CONCLUSIONThe reactivity of intrapulmonary arterial rings is significantly decreased in patients with COPD.
