Effect of topical application of a recombinant adenovirus carrying promyelocytic leukemia gene in a psoriasis-like mouse model.
- Author:
Qiongyu WANG
1
;
Aijun ZHANG
;
Huiqun MA
;
Shijie WANG
;
Yunyun MA
;
Xingwei ZOU
;
Ruilian LI
Author Information
- Publication Type:Journal Article
- MeSH: Adenoviridae; genetics; Administration, Topical; Animals; Cell Proliferation; Disease Models, Animal; Epithelial Cells; cytology; Female; Genetic Vectors; Male; Mice; Mice, Inbred Strains; Mitosis; Nuclear Proteins; genetics; Promyelocytic Leukemia Protein; Psoriasis; therapy; Skin; cytology; Transcription Factors; genetics; Tumor Suppressor Proteins; genetics; Vagina; cytology
- From: Journal of Southern Medical University 2013;33(3):432-435
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of topical treatment with adenovirus-mediated promyelocytic leukemia gene (PML) gene in a psoriasis-like mouse model.
METHODSThe effect of adenovirus-mediated PML gene on the granular layer of mouse tail scale epidermis and epithelial mitosis were observed on longitudinal histological sections prepared from the tail skin and vaginal epithelium of the mice.
RESULTSAdenovirus-mediated PML gene significantly inhibited mitosis of mouse vaginal epithelial cells and promoted the formation of granular layer in mouse tail scale epidermis.
CONCLUSIONThe therapeutic effect of PML gene in the psoriasis-like mouse model may be associated with increased granular cells and suppressed epidemic cell proliferation.
